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We validated the deficient cleavage process and the loss of protease function in this mutant form of HPN in our previous publication (Hsu et al

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The findings of the rapid and long-lasting antidepressant effects of LAC (which increases the expression of mGlu2, inhibitor of spontaneous glutamate release) supports the idea that targeting the glutamate system can lead to rapid antidepressant effects in agreement with the prior discovery of the antidepressant action of ketamine [48,49,50]